Fig. 1

Schematic representations of the experimental schedule. Fear conditioning was performed in a square box（context A） at 12 weeks of age. 24 hours later, cued fear extinction 1 was performed in a triangular box（context B）. 24 hours after extinction 1, extinction 2 was performed in context B. 78 weeks later, a contextual memory test was performed in context A that had been used for fear conditioning at 12 weeks of age. 24 hours later, a cued memory test was performed in context B that had been used for extinction sessions at 12 weeks of age. 24 hours after the cued memory test, a renewal test was performed in context A. 24 hours later, fear conditioning trial 2 was performed in context A in mice 90 weeks of age.