Fig. 3　Association between disease severity and tau PET accumulation. In patients with advanced PSP, remarkable uptake of PM-PBB3 was observed in the cerebral cortex as well as in subcortical regions (red arrowhead). Yellow arrowheads indicate off-target binding to the choroid plexus. HC, healthy control; AD, Alzheimer’s disease; MCI, mild cognitive impairment; PSP, progressive supranuclear palsy