Fig. 1　The scheme of the SETD1A/COMPASS complex. The COMPASS complex catalyzes H3K4me3, resulting in active transcription. It also catalyzes mono-methylation of K342 of YAP, followed by active transcription. FLOS activates transcription via the release of paused RNA polymerase II in a non-catalytic-dependent manner. Abbreviations for domains and proteins are the followings: RRM, RNA recognition motif; WDR82, WD repeat-containing protein 82; FLOS, Functional location on SETD1A; CDK12, Cyclin dependent kinase 12; RNAP2, RNA polymerase II; TEAD, TEA domain transcription factor; SET, Suppressor of variegation 3-9, enhancer of zeste and trithorax; NSET, N-terminal of SET; Post-SET, C-terminal of SET; HCF, Host cell factor C1; CFP1, CXXC finger protein 1; WDR5, WD-40 repeat-containing protein 5; RbBP5, Retinoblastoma-binding protein 5; ASH2L, Ash2 (Absent, Small, Or Homeotic) -like; DPY30, Dumpy-30.