Fig. 1

Examples of RFLP patterns of SmaI digested DNA of H. influenzae type b strains from patients with purulent meningitis. In 18 patients（patients 3-9 and 11-21）, RFLP patterns of the 3 isolates were identical（Fig. 1-a）. In 4 patients（patients 1, 2, 10, and 22）, the patterns were identical except 1 strain in which a single band shift of approximately 20 kb was identified（Fig. 1-b）. Lanes: C, isolate from cerebrospinal fluid; B,from blood; N, from nasopharynx; M, lambda ladder molecular size marker.