Fig. 3

Discrepancy of RFLP patterns of ApaI digested DNA between isolates from cerebrospinal fluid, blood, and nasopharynx of 4 patients. In all patients, a difference in the ～ 120 kb fragment was observed in 1 of 3 strains（ arrow）.
Patient 1, the isolate from the blood showed a singlebandshift of approximately ＋20 kb;
patient 2, the strain from the cerebrospinal fluid showed a shift of approximately －20 kb;
patients 10 and 22, strains from the nasopharynx showed a shift of approximately －20 kb shift.
Lanes:
　C, isolate from cerebrospinal fluid;
　B, from blood;
　N, from nasopharynx;
　M, lambda ladder molecular size marker.