Fig. 1 Th subsets and the IRF-BATF complex

When naïve CD4⁺ T cells are activated, microenvironmentderived cytokines induce the differentiation of naïve CD4⁺ T cells to distinct Th subsets. Six different Th subsets are characterized by the expression of master regulators (depicted as bold) and effector molecules. IRF4 and BATF regulate some master regulators and effector molecules cooperatively or independently.