Fig. 2 IRF-BATF complexes open the chromatin to initiate a lineage-specific program

(A) IRF4-BATF complexes bind closed chromatin and open the chromatin. (B) Lineage-specific transcription factors (LSTFs) are subsequently recruited to opened chromatin. LSTF and IRF4-BATF complexes cooperatively induce a subset of specific master regulators (MRs) . (C) MR, LSTF, and IRF4-BATF complexes fully activate target gene (TG) loci.