Fig. 2

Severe impairment of passive cutaneous anaphylaxis in the absence of IKK2.

For passive cutaneous anaphylaxis （PCA）, WT or IKK2-/- mast cells were injected intradermally into the right ear of W/Wv mice. Four weeks later, mice were first primed with antigen-specific IgE by intradermal injection twenty-four hours later, the mice were injected with antigen. The degree of PCA was estimated by quantification of ear swelling. P＜0.01. （ref.3）