Fig. 3

Severe impairment of systemic anaphylaxis in the absence of IKK2.

For systemic anaphylaxis, we injected WT or IKK2-/-mast cells, into W/Wv mice to elicit systemic anaphylactic reactions. Four weeks later, mice were primed with antigen-specific IgE by i.v. injection. After another twenty-four hours, mice were injected with antigen and the systemic anaphylactic response was monitored by measuring rectal temperature. *P＜0.01. （ref.3）