Fig. 4

IKK2 plays critical roles in mast cell degranulation.

（A） IgE-induced β-hexosaminidase release is impaired in IKK2-/- mast cells. WT or IKK2-/- mast cells were cross-linked upon FcɛRI. Thirty minutes later, β-hexosaminidase activity in the supernatants and lysate of the cell pelletes was quantified. *P＜0.01. （B） IgEinduced histamine release is impaired in IKK2-/- mast cells. WT or IKK2-/- mast cells were cross-linked upon FcɛRI. Thirty minutes later, cell-free supernatants were recovered. Histamine was measured by EIA. *P＜0.01. （ref.3）