Fig. 1　Roles of KMT2A-r, SETD1A, and SETD1B in AML. A)

Partner proteins (orange) involved in non-catalytic functionsand their interacting domains. The catalytic SET domain and the WARD complex responsible for H3K4 methylation are also indicated. B) Illustration of representative H3K4 methyltransferases in transcriptional activation in AML cells. Such transcriptional activations promote the self-renewal of AML-initiating cells.